Changes occurred in the lives of the Indigenous Mesoamericans because of the Spanish invasion. Describe the changes to indigenous land, food, worldview (religious practices) Because of the Spanish invasion, the lives of the indigenous Mesoamericans changed. Describe how indigenous land, food, and worldview have changed (religious practices) and language because of the Conquest. What affect did the Spanish had on the indigenous peoples of Mesoamerica during the conquest and colonial period? Include specific examples from central Mexico and from the Maya area.